- Ladd's rescue of Lua on top of the train.
- Ennis breaking down in tears after meeting Isaac and Miria for the first time. The novels drive it home by stating that this was the first time she had ever genuinely smiled or cried.
- A couple different times with Czes; when he's rescued by Isaac and Miria and they tell him he's a good boy, and when he is reunited with Maiza.
- The ending theme. It will bring tears to your eyes, no matter how lighthearted the series is.
- Nice accidentally blowing herself up. Becomes even more heartbreaking when you realize that she was eight at the time.
Baccano/Tear Jerker
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