In the adventure game Bad Mojo, protagonist Roger Samms' mother died giving birth to him, and he grew up with his father resenting him for it. In what is far from a coincidence, his landlord Eddie's late wife died giving birth to their son...
Psycho Mantis's Freudian Excuse in Metal Gear Solid is that his mother died in childbirth, prompting his father to blame him for her death. When his Psychic Powers developed, he read his father's mind, and saw how much his father hated him. He was overwhelmed, blacked out, and woke up hideously scarred with his hometown in flames.
In Fallout 3 this is what happens to the PC's mother at the very start of the game.
In the added backstory in the Nintendo DS version of Final Fantasy IV, Cecil's mother died giving birth to him. For Cecil's elder brother Theodor, her death combined with Kluya's death just shortly earlier is what allows Zemus to gain control of Theodor and turn him into Golbez.
This is part of Gau's backstory in Final Fantasy VI. His mother's death is what caused his father to go mad and leave him in the Veldt. The Japanese and the retranslated versions also stated that Edgar and Sabin's mother died giving birth to them. And then then there's Relm's mother.
This is the offical explanation of what happened to Sephiroth's mother "Jenova" in Final Fantasy VII. Besides that, his actual, human mother Lucrecia Crescent tried to kill herself shortly after he was born due to her guilt over the experiments on him and ended up vanishing from the public eye, freezing herself in crystal to atone. The way it was translated originally made it sound a lot like she died in childbirth and Cloud and Co. actually met her ghost later on.
In FFVIII Squall's mother Raine died in child birth and he was sent to the orphanage.
Silent Hill 3 has an utterly bizarre example that technically fits the trope, involving the demon Fetus Terrible in Heather's womb which will kill her when it's born, and actually does kill Claudia after she eats it (it's a long story). And if the player doesn't figure out what to do to cause this scene, then Heather will suffer the consequences.
Commonly assumed to be the case with Marowak and Cubone in Pokémon based on the latter's Pokédex entry.
In Dragon AgeOrigins the assassin Zevran's mother died giving birth to him and he was raised in the whorehouse she worked in before being sold to the Crows. Zevran seems to blame himself for it, referring to her as his "first victim". One of the unique gifts one can give him (for quite a few approval points) is a pair of Dalish gloves similar to the ones his mother left behind.
Alistair's mother died giving birth to him, too. For extra points, he was the illegitimate son of the king, and his half-sister Goldanna blames him for their mother's death (and just about everything else).It's subverted, actually: Alistair's mother is the ex-Grey Warden Fiona, now an important mage from Orlais, who was the lover of King Maric in the past. She gave baby!Alistair away and explicitly asked for her identity as his mom to remain a secret.
In the backstory of the Fire Emblem Akaneia games, Anri the Hero's beloved Princess Artemis not only couldn't marry himfor his lowborn origins, but died when she gave birth to her and Duke Cartas' kid. She's said to have cursed the Fire Emblem itself in what's known as Artemis' Curse, which would bring misfortune to her descendants and to anyone who tries to use the Emblem itself.
Fanon dictates that Emmeryn, Chrom and Lissa's mother in Fire Emblem Awakeningmay have died after giving birth to Lissa. It has also been cited by Fire Emblem Fates as a possibility for Queen Ikona aka the birth mother of the Hoshidan Royals (after she had Sakura alias the youngest princess, of course).
Fire Emblem: Three Houses has Byleth's mother Sitri dying like this in the backstory. Their father Jeralt never blames their son/daughter for it, in fact he tells them that Sitri loved them very much even when she could never fully meet them and even gives them a ring that belonged to her. It's later revealed that baby!Byleth was a stillborn while the Ill Girl Sitri barely survived but knew that she would die soon of complications... so she asked her Parental Substitute / Jeralt's boss Lady Rhea, the Archbishop of the Church of Seiros, to give them a certain "crest of Flames" that she had, fully knowing that it'd kill her yet give Byleth a chance to live.
It's believed by The King of Fighters fans that IoriYagami's mother died like this due to the Orochi curse afflicting the descendants of the Yagami clan. The curse is very powerful and physically painful on the Yagamis, so it's not out of the question.
