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The four main girls in the dorm from Ai Kora fit into this:

Choleric Melancholic Phlegmatic

Sanguine

Sakurako Yukari Kirino (mostly) Tsubame

Azumanga Daioh

Chol-Sanguine

Melan-Choleric

Sup-ancholic

Sang-Supine

Phlegmatic
Tomo Yomi Sakaki Chiyo-Chan Osaka

Baka and Test: Summon the Beasts

Choleric Melancholic Phlegmatic

Sanguine

Boys

Akihisa Yoshii Hideyoshi Kinoshita Yuuji Sakamoto Kouta Tsuchiya

Girls

Minami Shimada Mizuki Himeji Shouko Kirishima Aiko Kudou

Shuya's closest friends before the program begins in Battle Royale fit into this:

Choleric Melancholic Phlegmatic

Sanguine

Shinji Hiroki Yoshitoki Shuya
  • As it appears to be, though Yoshitoki is killed before we get to learn much about him.

The titular band in Beck fits this even better than the Five-Man Band pattern:

Choleric Melancholic Supine

Sanguine

Phlegmatic
Ryuusuke (charismatic, ambitious) Taira (calm, collected) Saku Chiba (hot-blooded) Koyuki (the everyman)
  • Only Saku's Supine nature is perhaps not so immediately obvious, but he keeps constantly worrying about his skill level holding the band back, even though he's a really good drummer.

Beyblade

(Teams) Blade Breakers

White Tigers

All Starz

Majestics

Demolition Boys

Sanguine

Max Mariah Michael Enrique Ian
Choleric Tyson Kevin Steven Johnny Spencer
Melancholic Kai Lee Emily Robert Tala
Phlegmatic Ray Gary Eddie Oliver Bryan

Although everyone in Big Windup gets his/her turn to shine, the story tends to focus on four core members of the baseball team:

Choleric Melancholic

Supine

Sanguine

Captain Hanai Strategist Abe Fragile Flower Mihashi Cloud Cuckoolander Tajima

Black Lagoon

Choleric Melancholic Phlegmatic

Sanguine

Sociopathic Hero Revy Wide-Eyed Idealist Rock Dutch Benny

The four deadliest women within the series as well:

Choleric Melancholic Supine Sanguine
Trigger Happy Revy Manipulative Bitch Balalaika The Dreaded Roberta Dragon Lady Shenhua

The "main" cast in Bleach:

Choleric Melancholic Phlegmatic

Sanguine

"Main" Cast

Uryu Ichigo Chad Rukia/Orihime

Urahara's

Shop Staff

Jinta Ururu Urahara Tessai

The original Bubblegum Crisis:

Choleric Melancholic

Sanguine

Phlegmatic II

Priss (hot-blooded Badass) Sylia (Stoic leader) Nene (perky & ditzy) Linna (the average Jane)

Chrono Crusade

Sanguine

Rosette Hot-Blooded, with much care for others but also a violent temper
Choleric Satella Prideful, determined, and focused on her revenge
Melancholic Chrono Compassionate and nurturing, but easily discouraged

Supine

Azmaria A prodigy singer, very caring about others, but insecure and hard on herself

The Absurdly Powerful Student Council from Code Geass:

Choleric Melancholic

Supine

Sanguine

Phlegmatic
Lelouch/Kallen

(phleg II facade)

Suzaku Nunally/Nina Shirley/Milly Rivalz

The Cowboy Bebop crew fits perfectly, with even the colors of their hair (or clothes in Faye's case) signifying their humors:  

Choleric Melancholic

Supine

Sanguine

Hot-tempered Faye high-strung Jet Spike, through and through Ed (the space case variety)
V.T. Vicious & Vincent Julia & Gren Appledehli

The Wammy's House residents from Death Note:

Choleric Melancholic Phlegmatic

Sanguine

Mello L Near Matt

The boys of Digimon Adventure:

Choleric Melancholic

Supine

Sanguine

Phlegmatic
Tai Matt Joe TK Izzy
  • The four Dark Masters also fit:
Chol-Sanguine Puppetmon Hot-Blooded Psychopathic Man-Child demeanor

Melan-Choleric

Machinedramon Cold and calculating Evil Genius

Sup-ancholic

Metalseadramon Pragmatic, good boss to his minions, long as they don't fail him

Sang-Supine

Piedmon The leading element

Digimon Savers has two sets:

Choleric Melancholic

Supine

Sanguine

Savers

Hot-Blooded Marcus Teen Genius Thomas Faux Action Girl Yoshi Wild Child Keenan

Original

Genius Bruiser Spencer Big Bad Kurata Good Parent Criers Cool Old Guy Yushima

Digimon Tamers

Choleric Melancholic Phlegmatic

Sanguine

Rika Takato Henry Jeri

The main girls of Doujin Work:

Choleric Melancholic Phlegmatic

Sanguine

Najimi Kaneru Tsuyuri Sora

The Z-fighters from Dragon Ball (excluding Krillin, Yamcha, and Chiaotzu):

Choleric Melancholic

Supine

Sanguine

Phlegmatic
Vegeta Piccolo Gohan Goku Tienshinhan

Elfen Lied:

Choleric Melancholic

Supine

Sanguine

Phlegmatic
Yuka Lucy/Kaede Mayu Kohta Nana

In Endride, the central four Ignauts demonstrate these traits:

Sanguine

Demetrio The dynamic and idealistic Rebel Leader
Choleric Louise The cynical but lively bruiser
Melancholic Felix The taciturn but ultra-loyal follower

Supine

Eljuia The peaceful and empathetic seer

Although there are six main characters, this can work for Et Cetera, too:

Choleric Melancholic Phlegmatic/Supine

Sanguine

Phlegmatic II
Fino Benkate Alternate, Baskerville Mingchao Yaghi
  • As an alternative, Mingchao can also be seen as Melancholic while Benkate is Sanguine.

Eyeshield 21

Choleric Melancholic Phlegmatic

Sanguine

Ojou Takami Shin Sakuraba Ootawara
Kyoshin the Hiroshis Kakei Kobanzame Mizumachi

Fairy Tail, Natsu (sanguine), Lucy (supine), Gray (phlegmatic Type I), and Erza (choleric).

Fist of the North Star has the four Hokuto brothers:

Choleric Melancholic

Supine

Sanguine

Jagi Kenshiro Toki Raoh

If you divide the cast in Fullmetal Alchemist into different groups, it's easy to see this. Of the main protagonists: Ed (choleric), Alphonse (phlegmatic), and Winry (sanguine). Of the soldiers: Roy (choleric), Armstrong/Hughes (sanguine), and Riza (melancholic).

  • Roy's male subordinates: Jean Havoc (sanguine), Heymans Breda (choleric), Vato Falman (melancholic), and Kain Fuery (phlegmatic).
  • (2003 Anime) The homunculi: Wrath & Gluttony (sanguine), Envy & Pride (choleric), Lust & Sloth (melancholic), and Greed (phlegmatic).

Ghost in the Shell: Stand Alone Complex:

Choleric Melancholic Phlegmatic

Sanguine

Chief Aramaki Motoko Kusanagi Togusa Batou

The Le Creuset team in Gundam Seed kinda fits this: Athrun (melancholic), Yzak (choleric), Dearka (phlegmatic), and Nicol (supine). The four main leads as well with Kira and Athrun being phlegmatic and melancholic, respectively, Cagali being choleric and Lacus being sanguine.

  • The Minerva pilots in Gundam Seed Destiny possess two temperaments: Shinn is both Sanguine and Melancholic, Athrun is Choleric and Melancholic, Ray is both Melancholic and Phlegmatic and Lunamaria is Sanguine and Supine.

Gundam Wing

Choleric Melancholic Phlegmatic

Sanguine

Chang Wu Fei Heero Yuy Trowa Barton &

Quatre Winner

Duo Maxwell

Gurren LagannEarly episodes:

Choleric Melancholic Phlegmatic

Sanguine

Yoko Simon Leeron Kamina

The four main boxers from Hajime no Ippo fit this well:

Chol-Sanguine

Melan-Choleric

Sup-ancholic

Sang-Supine

Takamura Aoki Kimura Ippo

Hellsing has three:

Choleric Melancholic

Supine

Sanguine

Phlegmatic

Hellsing

Organization

Alucard Walter Integra & Seras Pip Walter

Iscariot

Heinkel Wolfe Enrico Maxwell ------ Alexander Anderson Yumie Takagi

Millennium

Schrodinger The Captain ------ The Major Doctor

Hunter X Hunter:

Choleric Melancholic Phlegmatic

Sanguine

Killua Kurapika Leorio Gon

Jewelpet

  • Jewelpet Happiness has the boys' quartet:
Choleric Melancholic Phlegmatic

Sanguine

Taira Takumi Kousuke Mouri
  • Lady Jewelpet has two sets:
Choleric Melancholic

Supine

Sanguine

Phlegmatic

Petit Ladies

Mizuki Lillian Sixth Ranger Elena Momona Charon

The Princes

Sixth Ranger Miura Soarer Cayenne Levin Romeo

JoJo's Bizarre Adventure Stardust Crusaders:

Choleric Melancholic

Supine

Sanguine

Phlegmatic
Jotaro Kujo Mohammad Avdol Noriaki Kakyoin Jean Pierre Polnareff Joseph Joestar

K-On!!

Chol-Sanguine

Melan-Choleric

Sup-ancholic

Sang-Supine

Ritsu Mugi Mio Yui

Kara no Kyoukai

Choleric Melancholic Phlegmatic

Sanguine

Aozaki Touko Ryougi Shiki Kokutou Mikiya Kokutou Azaka

KamenRider Den-O's four Imagin:

Choleric Melancholic Phlegmatic

Sanguine

Momotaros Urataros Kintaros Ryutaros

The main cast of Katekyo Hitman Reborn: Tsuna (phlegmatic), Gokudera (choleric), Yamamoto, Lambo and Ryohei (all sanguine), Hibari (melancholic), and Mukuro (choleric/sanguine). Chrome is supine. Keroro Gunsou follows the 5-humor style:

Choleric Melancholic

Supine

Sanguine

Phlegmatic
Giroro Dororo Keroro Tamama Kururu

Kill La Kill has three groups:

  • Main characters:
Chol-Sanguine Ryuko Hot-Blooded nature and single-minded determination to get the answers she wants out of Satsuki.

Melan-Choleric

Satsuki Focuses on accomplishing her plans and using whatever means necessary to do so, and cares very little for anything that hinders her progress.

Sup-ancholic

Senketsu Mostly interested in assisting Ryuko's quest and protecting her from harm's way, as well as try to keep her extreme temper under control.

Sang-Supine

Mako The Plucky Comic Relief interested in having fun with Ryuko, and seems to know just what to say in a given situation to snap people out of their funk.
  • The Elite Four:

Sanguine

Jakuzure A driest sense of humor. She also takes great pride in the fact that she's known Satsuki the longest.
Choleric Sanageyama Fight-happy swordsman interested only in finding opponents that can challenge him.
Melancholic Gamagoori Firm disciplinary officer and enforcer of Satsuki's rules, and the most overt in loyalty towards her.
Phlegmatic Inumuta Preferring to gather and study as much data as possible rather than take an active field role like the others.
  • The Kiryuin Conglomerate:

Sanguine

Mind-Controlled Ryuko Says her emotions bluntly, taking them (sometimes literally) to the person she speaks to. Ryuko even kisses Nui, showcasing their love for each other. She balances out the others' negative emotions by being compassionate with them and follows after Ragyo by being way over-the-top in battles, but as a negative, mind-controlled into finally finding her wants of an actual family; comes off as harsh to others.
Choleric Ragyo The Big Bad of the series and an all-around pompous character when she gets her moments. Showcasing the negatives more than the positives — had abnormally high wants when she was testing her own daughters, but filled with glee when they finally do fulfill them.
Melancholic Nui Arguably Co-Dragons with Rei to Ragyo, and the one who gets the most work done initially while Ragyo sits around and controls REVOCS. Showcases the downside by being outwardly nice, extremely crazy inside, and even more insane after normal Ryuko cuts off her arms.
Phlegmatic Rei The person able to serve at a moment's notice, and without question. Being however, on the downside, outwardly a cold person, exemplified in the OVA by being a Defrosting Ice Queen when she heard of Ragyo's death, and was able to be swayed by Satsuki.

Kiss Him, Not Me: The main four boys:

Sanguine Choleric Melancholic Phlegmatic
Yuusuke Igarashi Nozomu Nanashima Hayato Shinomiya Asuma Mutsumi

The Legend of Zelda by Akira Himekawa: the flash-animations by Hadouken Dude took this to absolutely hilarious levels:

Sanguine

Orchid Link The childish, mischievous and clumsy noob
Choleric Red Link The self-centered, temperamental and trouble-making Jerkass
Melancholic Green Link The fearless, determined and uptight leader

Supine

Blue Link The analytical, cautious, and mildly snarky intellectual

The Hinata House Girls in Love Hina:

Choleric Melancholic

Supine

Sanguine

Phlegmatic
Naru Narusegawa & Motoko Aoyama Mitsune Konno Shinobu Maehara Kaolla Su Mutsumi Otohime

Lucky Star

Choleric Melancholic

Supine

Sanguine

Kagami Miyuki Tsukasa Konata
  • None of the main characters can really qualify as either definition of Phlegmatic.

Magical Girl Lyrical Nanoha StrikerS

Sanguine

Subaru Genki Girl Pollyanna
Choleric Teana natural leader and (former) Tsundere
Melancholic Erio Introverted knight-in-training
Phlegmatic Caro Other introvert
Choleric Melancholic Phlegmatic

Sanguine

Hayate's

Knights

Vita Signum Zafira Shamal

Combat

Cyborgs

Nove Dieci Clinque Wendi

Magical Pokaan's four girls match:

Choleric Melancholic Phlegmatic

Sanguine

Pachira Aiko Liru Yuuma

Kozu's five personalities in Mahoraba:

Choleric Melancholic Phlegmatic

Sanguine

Saki Natsume Chiyuri Kozue & Nanako
  • As Nanako is merely the kid version of Kozue.

Mahou Sensei Negima: some of the "main" girls in 3-A and the four sports stars.

Choleric Melancholic

Supine

Sanguine

Phlegmatic

Girls

in 3-A

Asuna Setsuna Nodoka Kuu Yue & Konoka

Sports

Stars

Yuna Ako ------ Makie Akira

The Melancholy of Haruhi Suzumiya - including Tsuruya, an honorary member of the Brigade:

Choleric Melancholic

Phlegmatic/Supine

Sanguine Phlegmatic II
Haruhi (despite

the title)

Koizumi Yuki, Mikuru Tsuruya Kyon

The Gundam Meisters in Mobile Suit Gundam 00 fit this:

Choleric Melancholic Phlegmatic

Sanguine

Tieria Allelujah Setsuna Lockon

The main monster girls of Monster Musume:

Sanguine Choleric Melancholic Phlegmatic II Phlegmatic
Miia, Papi & Suu Centorea Rachnera Lala Mero

Team Kakashi in Naruto: Naruto (sanguine), Sakura (choleric), Sasuke (melancholic). Kakashi was also melancholic, as he was the "Sasuke" of his own three-man team as a kid, although he's currently phlegmatic. His partners (the "Naruto" and the "Sakura", respectively) were sanguine Obito and supine Rin.

A good example is probably Neon Genesis Evangelion:

Choleric Melancholic

Supine

Sanguine

Asuka Rei Shinji Misato
  • Though he rarely appears, Kaworu can fit here as Phlegmatic II since he seemingly has absolutely no internal turmoil whatsoever.

Nerima Daikon Brothers:

Choleric Melancholic Phlegmatic

Sanguine

Hideki Ichiro Team Pet Pandaikon Mako

One Piece's main male cast:

Choleric Melancholic Supine

Sanguine

Phlegmatic
Zoro Usopp Tony Tony Chopper Luffy Sanji

Although everyone in Ookiku Furikabutte gets their turn to shine, the story tends to focus on four core members of the baseball team:

Choleric Melancholic Phlegmatic

Sanguine

Hanai Abe Mihashi Tajima

The main characters of Panty & Stocking with Garterbelt:

Sanguine Melancholic Choleric Supine
Panty Stocking & Corset Garterbelt & Scanty Brief & Kneesocks

Ash's original main four in the Pokémon anime: Pikachu (choleric), Bulbasaur (melancholic), Squirtle (sanguine), and Charmander/Charmeleon/Charizard (phlegmatic).

  • Original Series - Ash (sanguine), Pikachu (supine), Tracey (ironically melancholic), Misty & Delia, aka Dyslexia (choleric), and Brock (phlegmatic).
  • Advanced Generation - Ash (choleric), May (sanguine), Max (melancholic), and Brock (phlegmatic Type II). If you count Pikachu here, he becomes the Supine.
  • Diamond and Pearl - Ash (choleric), Dawn (sanguine), Pikachu (phlegmatic), and Brock is (phlegmatic).

The four ARMS teenagers in Project ARMS. Ryo (phlegmatic), Hayato (choleric), Takeshi (sanguine), and Kei (melancholic).

Puella Magi Madoka Magica: Sayaka (sanguine), Kyoko (choleric), Homura (ironically melancholic), Mami & Madoka (phlegmatic).

Ranma ½

Choleric Melancholic Phlegmatic

Sanguine

Akane Ryoga Genma Ranma

The main cast of Rurouni Kenshin

Chol-Sanguine

Melan-Choleric

Sup-ancholic

Sang-Supine

Phlegmatic
Sano Yahiko Megumi Kaoru Kenshin

Saber Marionette J

Choleric Melancholic Phlegmatic

Sanguine

Bloodberry Cherry Otaru Lime

Sailor Moon

Choleric Melancholic Supine

Sanguine

Phlegmatic

Outer

Senshi

Haruka/Sailor Uranus Setsuna/Sailor Pluto ---- Michiru/Sailor Neptune Hotaru/Sailor Saturn

Inner

Senshi

Rei/Sailor Mars (in the anime) Makoto/Sailor Jupiter Ami/Sailor Mercury Usagi/Sailor Moon Minako/Sailor Venus

Saint Beast

Choleric Melancholic Phlegmatic

Sanguine

Goh Rei Shin Gai

Saiyuki also has two. For the Sanzo party, Goku (sanguine), Sanzo (choleric), Hakkai (melancholic), and Gojyo (phlegmatic). For Kougaiji's group, Lirin (sanguine) and Kougaiji (choleric). Yaone and Dokugakuji switch off between melancholic and phlegmatic, although neither of them are actually lazy The current lineup of the Taishiro in Samurai Deeper Kyo fits almost flawlessly.

Sanguine

Yuan Extroverted, fond of wisecracks, and very protective of the people he cares about. Wears red and uses fire techniques.
Choleric Tokito Perfectionistic, impulsive, and quick to anger. Wears shades of yellow and fights with a fiercely aggressive energy.
Melancholic Hishigi Exceedingly introverted and the epitome of the Stoic, analytical and extremely task-focused; plus textbook signs of severe depression. His color scheme is almost entirely black.
Phlegmatic Fubuki Level-headed, cultured and elegant leader of the Taishiro. Color scheme mainly blue and fighting style revolves around water.

Sayonara, Zetsubou-sensei: Kafuka (sanguine), Nami (phlegmatic), Chiri (choleric), and Itoshiki-sensei (melancholic).

  • Maria (sanguine), Harumi/Kiri/Matoi/Other relatively sane characters (phlegmatic), Kaere (choleric), and Abiru (melancholic).

School Rumble's main girls, counting Tenma's sister Yakumo:

Choleric Melancholic

Supine

Sanguine

Phlegmatic
Mikoto Ari Yakumo Tenma Akira

The Slayers characters fit perfectly into these categories, if you count one of their secondary allies:

Choleric Melancholic

Supine

Sanguine

Phlegmatic
Lina Zelgadis Sylphiel Amelia Gourry

Soul Eater

Choleric Melancholic

Supine

Sanguine

Phlegmatic
Maka Death the Kid Tsubaki & Liz Black☆Star & Patti Soul

Superbook (second season):

Choleric Melancholic Phlegmatic

Sanguine

Christopher Peepers Joy Gizmo Uriah

The four main characters from Texhnolyze:

Choleric Melancholic Phlegmatic

Sanguine

Onishi Ran Ichise Doc

Ensemble of five in Tokyo Mew Mew:

Choleric Melancholic

Phlegmatic

Supine

Sanguine
Ichigo Minto Retasu Genki Girl Bu-Ling Zakuro
  • Ironically enough, Ichigo was at first not happy about leading, but she began accepting her responsibility later on.

The Tower of Druaga

Choleric Melancholic

Supine

Sanguine

Phlegmatic

Jil's Group

Melt Jil Ahmey Coopa Kaaya

Neeba's Group

Fatina Neeba Kally Utu ------

Trigun more often averts this trope in favor of the Lone Hero or the Power Trio. Adding Wolfwood to the cast has instead a subtractive effect, generating a duo dynamic that leaves Meryl and Millie on the sidelines. When they participate equally, they fit the four temperaments.

Choleric Melancholic Phlegmatic

Sanguine

Meryl Vash (a pretend sanguine) Wolfwood Millie

Tsubasa Reservoir Chronicle: Sakura/Fay (sanguine), Syaoran (melancholic), Kurogane (choleric).

The four aunts in Umineko no Naku Koro ni. Natsuhi (melancholic), Rosa (sanguine), Eva (choleric), and Kyrie (phlegmatic). Probably works with the uncles and cousins too. Have to try that later.

  • The Higurashi girls can be categorized this way. Really, both Shion and Keiichi could fit their position.
Choleric Melancholic

Supine

Sanguine

Phlegmatic
Shion Rika Satoko Rena Mion

The original Weiss Kreuz:

Choleric Melancholic Phlegmatic

Sanguine

Aya Omi Youji Ken
  • Between the choleric personality and being the focus character, casual fans often mistake Aya for being the team leader--it's actually Omi.

Wolf's Rain

Choleric Melancholic Phlegmatic

Sanguine

Tsume Kiba Toboe Hige

Yes! Pretty Cure 5 tries to throw us off by having four temperaments among five characters — Nozomi and Urara (both sanguine), Rin (choleric), Komachi (melancholic), and Karen (phlegmatic, though not lazy by any stretch).

Your Lie in April

Choleric Melancholic Phlegmatic

Sanguine

Miyazono Kaori Arima Kousei Sawabe Tsubaki Watari Ryota

The main four of Yu Yu Hakusho:

Choleric Melancholic Phlegmatic

Sanguine

Yusuke Kiei Kurama Kuwabara

Yu-Gi-Oh! (with 5D's for the second four):

Choleric Melancholic Phlegmatic

Sanguine

Yami Yugi Kaiba Yugi Joey
Jack Yusei Akiza Crow

Out of the four "Yu's" from Yu-Gi-Oh! Arc V:

Sanguine

Yuya Aspires to make people smile and peacefully solve conflicts, but can be emotionally unstable
Choleric Yugo Hot-tempered and occasionally impulsive, but is ambitious and protective of loved ones
Melancholic Yuto Determined, pragmatic, and stoic, but has a self-blaming and cynical streak
Phlegmatic Yuri Always level-headed and calm, even when relentlessly hunting people under orders of his leader, or being a comedic plaything
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