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Dr. Rick Dagless MD, Medicinae Doctor / Garth Marenghi (Matthew Holness)
- The Ace
- Author Avatar
- Badass Longcoat
- Bunny Ears Lawyer: Garth Marenghi is a successful novelist, but he's mad as a brush.
- Well, he claims to be a successful novelist. One gets the feeling that if his books sell at all it's because they're So Bad, They're Good.
- Carpet of Virility
- Cool Gun: Keeps a Magnum revolver on his person at all times, but...
- Dark and Troubled Past
- Dead Little Sister: His half-boy, half-grasshopper son.
- Deadpan Snarker
- Don't You Dare Pity Me!
- Eighties Hair
- Friend to All Children
- The Hero
- In Case You Forgot Who Wrote It: Marenghi is very fond of this trope.
- Large Ham
- Licensed Sexist
- Marty Stu
- Black Hole Sue
- God Mode Sue
- Jerk Stu
- Parody Sue
- Purity Sue: "You're the most sensitive man I know, and I know God."
- Sympathetic Sue
- Narrator: Oh, boy...
- Noble Bigot with a Badge
- What Do You Mean It's Not Awesome?: Every word out of his mouth.
Dr. Lucien Sanchez / Todd Rivers (Matt Berry)
- AcCENT Upon the Wrong SylLABle
- The Alcoholic: Todd Rivers, who hasn't worked since this show.
- Badass Longcoat
- Badass Spaniard: He tries to invoke this by wearing eye makeup and foundation to make him look like he might be Hispanic.
- The Cast Showoff: "One Track Lover". Doubles as a Big Lipped Alligator Moment.
- Classically-Trained Extra: Todd Rivers is one.
- Eighties Hair
- Estrogen Brigade Bait: Another Invoked Trope.
- The Gunslinger
- The Lancer
- Large Ham: "So what happened between you and this Renwick customerrrrrr?"
- Lip Lock: The most frequent offender.
- Really Gets Around: Implied in the last episode when it's stated that the broccoli infection is sexually transmittable. Also and Informed Attribute as Sanchez is never seen with any other woman apart from the broccoli infection victim and is constantly being shot down by Liz.
- Trigger Happy
- Vitriolic Best Buds: "He's a good buddy, though we sometimes have punch-ups."
- Wimp Fight
- The Worf Effect
Liz Asher / Madeline Wool (Alice Lowe)
- All Women Love Shoes
- The Big Girl
- The Chick
- Dumb Blonde
- Eighties Hair
- Ivy League: In her own words, she attended "Harvard College,Yale."
Thornton Reed / Dean Learner (Richard Ayoade)
- Badass Grandpa: Invoked. Badly. Very badly.
- Bad Bad Acting: Learner says he's not an actor, and he means it.
- Camp Straight
- Cool Old Guy: He's supposed to be one.
- Da Chief
- Directed by Cast Member: Richard Ayoade directed the series.
- Dull Surprise: "Good gravy."
- Gosh Dang It to Heck: Every one of his rants.
- Filming for Easy Dub
- Jive Turkey: Made hilarious by Learner's nasally English accent. "My ass is grass, and Wanton's got a lawnmower, ya dig?"
- Large Ham: Again, he's clearly meant to be played a Large Ham, but Learner is such a hilariously bad actor that it doesn't entirely work.
- Nice Hat: Several!
- Not-So-Badass Longcoat
- Reasonable Authority Figure
- Shotguns Are Just Better
- The Smart Guy
- The Sociopath: Learner in real life is strongly implied to be a serial killer.
- Waistcoat of Style