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- Hey, It's That Guy!: Among many others
- Tom Sizemore is the Big Bad.
- Bill Fichtner is your crooked lawyer friend.
- Philip Michael Thomas from Miami Vice is your sidekick.
- Danny Trejo and Miss Cleo are rival gang leaders.
- The late Dennis Hopper is a sleazy big-budget porn director with Jenna Jameson as his favorite leading lady.
- Jezz is Cooper and Soap.
- And of course, Player Character Tommy Vercetti is voiced by Ray Liotta.
- That is Ocean Drive.
- Let's Play: A well-regarded one was done by the Freelance Astronauts.