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- What Could Have Been: Tobey Maguire was originally intended for the lead human role, but when it fell through, they settled for James Franco instead. It's not the first time Harry Osborn has been second best to Peter Parker.
- Shown Their Work: Possibly. A leading theory for the cause of the rapid spread of AIDS in North America is "a promiscuous flight attendant". With even more air travel, and an easier route of transmission, the spread isn't that hard to believe.