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- The ending for episode 305. Max dies, and doesn't get better.
- When Papierwaite tells Sam that Max's tumor became infected with dark matter, and they won't be able to operate normally, instead of stepping back from the problem and trying to think of a solution like he normally would, he weakly, almost childishly, asks if Papierwaite can "make it better". This being Sam & Max, he obviously immediately follows with another hilarious quip, but he sounds so defeated when he says this, it cranks Sam's woobie factor Up to Eleven.