The Binding of Isaac/Characters

A list of characters who appear in The Binding of Isaac. Currently under construction, please contribute!

Isaac/Other Playable Characters

A little boy who gets thrown in the basement by his mother and has to fight for his life. Variations with different stats and starting items can be unlocked by gaining various achievements.

Shared Tropes

• Acrofatic: Several items make your character fatter. Combine these with items that increase your speed and you have this trope.
• Body Horror: With the right items Isaac can have this.
  • Borderlines with Lovecraftian Superpower in some cases.
• Break the Cutie: It's right in the title screen!
• Bullet Hell: For once the player can actually cause this with the right items.
• Collision Damage: Isaac cannot touch most of the enemies. There's an item which hurts the enemies as well when they touch Isaac.
• Cross Dresser: According to Edmund McMillen, the lead developer of the game, all of the playable characters are different forms of Isaac, this includes the female characters such as Eve.
• Deal with the Devil: It's possible. Isaac can make a deal with the devil at the Devil Room by offering his heart containers in exchange for powerups. By doing so, it prevents Isaac from using the Angel Room unless he has the Duality item.
• Detachment Combat: When using The Shears.
  • The Peeper pops out one of your eyes which bounces around the room, hurting everything it touches.
• Did You Just Punch Out Satan?
• Driven to Suicide: In at least one ending.
• Eye Scream: Some items cause this.
• Faustian Rebellion: The items Satan sells you at the cost of your maximum health often end up making beating him a lot easier.
• Flash of Pain
• Full-Frontal Assault: Isaac starts off without any clothes. Although he can find and pick up clothing items (such as the PJs blue suit) as he delves deeper in the basement.
• Hammerspace: It's not specified where can Isaac hold all the coins, keys and bombs he has collected.
• He Who Fights Monsters
• Ironic Name: "Isaac" means "he laughed" or "he who laughs." Not much laughing occurs.
  • Although it was based off the biblical story. See Meaningful Name below.
• Item Get: Holds up new items - even in battle.
• Meaningful Name: The Binding Of Isaac.
  • Foreshadowing: Right down to God preventing the murder/sacrifice at the very last second in at least one ending.
• Only One Name: Or no name at all in ???'s case.
• Swiss Army Tears: As a weapon!
  • Berserker Tears
  • Improbable Weapon User
  • Tears of Fear
  • Tears of Blood: Except this time it isn't a bad thing.
  • Ocular Gushers
  • Onion Tears: Once you find the Sad Onion powerup.
• Throw Down the Bomblet
  • Cartoon Bomb
• Took a Level In Badass: Start the game as a crying child and end it as a flying demon that can shoot lasers from their face.
• Troubled Fetal Position
• Undead Child: According to Edmund McMillan, the Blue Baby, the Keeper, the Forgotten and the Lost are modelled after Isaac's stages of decay.
• Urine Trouble: The aptly named Number One upgrade replaces his tears for a urine attack instead. It does seem to make him happier.
• Wall of Weapons: Potentially.
• Winged Humanoid: Possible with certain items.
  • Good Wings, Evil Wings: Both are possible.

Isaac

Isaac without any special accessories. The only character playable from the start. After beating It Lives with ??? Isaac starts with the D6: an activated item capable of transmuting any collection related item(s) into other random item(s).

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• Jack of All Stats
• Luck Manipulation Mechanic: The all-mighty D6 dice! An activated item capable of transmuting any collection related item(s) into other random item(s).
  • Magikarp Power
• True Final Boss: Of Wrath of the Lamb. More precisely, he is an alternate True Final Boss that can be fought instead of Satan. More details below.

Magdalene

Isaac with a blonde wig and a red bow. Maggy starts with the Yum Heart: an activated item that restores one heart upon use.

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• Combat Medic: Called "the cleric" in the art booklet.
• Everyone Calls Him "Barkeep": Usually referred to as Maggy.
• Stone Wall: Starts with low speed and 4 hearts, the highest starting amount possible, and an healing item.
• Tertiary Sexual Characteristics: She has a blonde wig and a red bow, which appears to be the same wig that Isaac receives in one of the mid-floor intermission scenes.

Cain

Isaac with an eye patch. Starts the game with the Luck Foot: a passive item that improves random events in various ways.

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• Born Lucky: Cain's starting item gives him increased luck in certain situations.
• Eyepatch of Power
• Fragile Speedster / Glass Cannon: Starts with great speed and attack and an average rate of fire but suffers from low range and health. Outright called "the thief" by the art booklet.

Eve

Isaac with a wig and eye shadow. Starts with The Whore of Babylon and the Dead Bird.

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• Attack Animal: The Dead Bird.
• Cast From Hit Points: The Dead Bird is activated by taking damage in a room and works as a faster level three Meat Boy for the room in which it activates.
• Critical Status Buff: When she's down to half a heart, her Whore of Babylon powerup grants her greatly increased attack.
• Cross Dresser
• Cursed with Awesome: The "curse" that Eve starts the game with. It gives her a super form when she's reduced to half a heart of health.
• Fragile Speedster: High speed, low attack, low health.
• Looks Like Cesare
• Tertiary Sexual Characteristics

Judas

Isaac with a fez. He starts the game with the Book of Belial, an activated item that increases attack power for one room.

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• Nice Hat
• Glass Cannon: More so then Cain. Starts with average rate of fire, range, speed and high attack power, further bolstered by his Book of Belial. In exchange, he starts with only 1 heart.

Samson

Isaac with long brown-hair and Big Ol' Eyebrows. He also starts with a red headband called Blood Lust, which grants him a temporary (last a whole room) but substantial attack-power boost for each enemy he kills. Introduced in Wrath of the Lamb.

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• Badass Long Hair
• Blood Knight: His trademark power-up is called Blood Lust, after all!
• Conservation of Ninjutsu: Invoked Trope by his special hair-band. The more enemies you face in a room, the more powerful you'll get! But single target rooms won't trigger any attack-boost.
• Glass Cannon: With just 1 starting heart container, he's as fragile as (and under some circumstances, even more than) Judas. However, his special gear makes him extremely effective against large groups of enemies and/or mook makers.
• Martial Arts Headband

??? / Blue Baby

A blue-skinned character with crossed eyes that resembles Isaac, ???'s stat is similar to Isaac. However, he does not have any red heart container. Instead, he starts with three soul heart and cannot gain any red heart.

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• Amazing Technicolor Population: Justified: he's dead.
• Back From the Dead
• Joke Character: He doesn't have any red heart container by default and he only has soul hearts. Unlike Azazel, who can gain red heart by collecting health up items, ??? can only have soul hearts.
  • Lethal Joke Character: Since he exists purely on soul hearts, he can benefit from Devil Room deals (which costs 3 soul hearts instead of 1 red heart) as well as the Whore of Babylon passive item, which boosts damage output when a character has less than one red heart, and since ??? cannot gain red heart, the damage boost will always be active.
• Joke Item: Starts with The Poop, which creates a pile of dung once per room. However, just like regular poops found in the maps, it can drop item pickups upon being destroyed.
• Jack of All Stats: Similar to Isaac, ??? has a balanced starting stat.
• Shout-Out: To Edmund McMillen's Newgrounds account (specifically his "Dead Baby Dressup" game).
• Wingding Eyes: Crossed-out eyes.
• Undead Child: Possibly the corpse of Isaac who decided to hide/went to in golden chest and suffocated there. According to Edmund McMillan, the Blue Baby is one of Isaac's stages of decay.

Azazel

A new character introduced in Rebirth, Azazel is a red-eyed demon with wings and a broken horn. He starts with the flight ability, a short-ranged Brimstone and The Fool card. He also starts with 3 Black Hearts and no heart container.

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• Bloody Murder: His Brimstone attack fires a stream of blood.
• Difficult but Awesome: Azazel doesn't start with any red heart container by default and his Brimstone's range is much shorter than tears. However, he can easily decimate bosses and enemies using his Brimstone attack and his default flight ability allows him to bypass numerous obstacles effortlessly. In the hands of a skillful player who is good at dodging and fighting against enemies at close range, Azazel can become a powerhouse.

Lazarus

A new character introduced in Rebirth, Lazarus has less range and luck than Isaac, but he has the ability to respawn upon death for once, in which he becomes Lazarus Risen, with increased stats as well as the Anemic passive item. If Challenge 31 has been beaten, then Lazarus would start with Anemic by default without the need of resurrecting as Lazarus Risen.

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• Lethal Joke Character: Lazarus has a below average stat compared to Isaac and when he gets resurrected into Lazarus Risen, he only has one heart container. However, unlike most extra life items that teleport the user to the previous room upon death, he has the benefit of being able to respawn at the same room upon death, which synergizes well with the Plan C pill, an item that instantly kill all bosses and enemies in a room but kills the user after 3 seconds, making him the only character who can instantly kill Delirium using the Plan C pill since Delirium has a death animation that lasts longer than 3 seconds.

Eden

A new character introduced in Rebirth, Eden has randomly generated hairstyle and stats based on a character seed. It also requires an Eden Token, a token earned by defeating Mom's Heart or It Lives to play as Eden.

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The Lost

A new character introduced in Rebirth, The Lost appears to be the ghost of Isaac. He starts with no heart container and will die from one hit. However, The Lost has the Flight ability and Spectral Tear by default, as well as D4 dice and Holy Mantle should they be unlocked. Moreover, he can accept deals of the devil for free.

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• Difficult but Awesome: The Lost has the least amount of health of all the characters and he will die from one hit. However, he can have Devil Deals for free without costing any heart. Moreover, the Whore of Babylon passive item damage buff would always be active since The Lost cannot obtain a Red Heart.
• One-Hit-Point Wonder: The Lost has no heart container, nor can he obtain one.

Lilith

A new character introduced in Afterbirth, Lilith is a red-haired, blindfolded demon. Being blindfolded, she cannot fire tears on her own. However, she starts with the Incubus familiar as well as Box of Friends and Cambion Conception, which makes her a character that specializes on familiars.

Keeper

A new character introduced in Afterbirth, Keeper appears to be one of the corpses found in the shops or secret rooms. He uses coins as health and restores his health by picking up coins. All other hearts would turn into friendly blue flies upon picking up them.

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• Undead Child: Implied to be Isaac's decomposing corpse in the Greed Mode's ending. According to Edmund McMillan, the Keeper is one of Isaac's stages of decay.

Apollyon

A new character introduced in Afterbirth+, Apollyon is a living statue with horns and non-functional small wings. He starts with the Void active item, which absorbs items on pedestals to gain active item abilities from the consumed active items and randomized stat increases from the consumed passive items.

The Forgotten

A new character introduced in Afterbirth+, the Forgotten is the skeletal remain of Isaac. He cannot fire normal tears. Instead, he uses a bone club as a melee weapon, which can be charged up and thrown as a boomerang projectile. Additionally, he can transform into The Soul, a ghost who fires spectral tears. Both The Forgotten and The Soul share the same health bar, each can carry up to 6 heart containers. The Forgotten can have up to 6 Bone Hearts and The Soul can have up to 6 Soul Hearts.

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• Bad with the Bone: He uses a bone club as his main weapon.
• Dem Bones: The Forgotten is a skeleton that resembles the Bony enemy. It's also implied to be Isaac's skeletal remain, left forgotten in the chest he's hiding in. According to Edmund McMillan, the Forgotten is one of Isaac's stages of decay.
• Deployable Cover: As the Soul, the Forgotten's skeletal body can be used as a makeshift cover that blocks projectile.

Bethany

A new character introduced in Repentance.

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Jacob & Esau

A new character introduced in Repentance.

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Tainted Characters

Alternate version of the characters introduced in Repentance. Tainted characters have drastically different character mechanics compared to the base characters, to which they can be considered as separate characters of their own They can be unlocked by unlocking a secret door at the Home level using the Red Key or Cracked Key, which would unlock the alternate version of the character that the player is currently playing as.

Shared Tropes

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• Corrupt the Cutie: Tainted characters are the result of Isaac being corrupted by Satan after being locked in a room by his mom after the Corpse route ending.

Tainted Azazel

An alternate version of Azazel. Tainted Azazel cannot fly and he has his short-ranged Brimstone replaced by a narrower, weaker version of Brimstone that has full range. Additionally, he starts with the Hemoptysis ability, which allows him to cough blood as a close range attack when the Brimstone isn't fully charged.

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Tainted Lilith

An alternate version of Lilith. Tainted Lilith starts with the C-Section ability, which allows her to launch her umbilical cord attached with a fetus as a whip and the fetus itself can fires tears.

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• Whip It Good: She uses her umbilical cord as a whip, and the fetus attached to it can fire tears for Tainted Lilith. The whip attack can inflict knockback on most enemies and bosses.

Tainted Forgotten & Tainted Soul

An alternate version of the Forgotten. Tainted Forgotten cannot move on his own. Instead, the player plays as the Tainted Soul, a ghost who carries Tainted Forgotten and throws the skeleton as his main means of attack. Tainted Forgotten can enter a room by being thrown at the door, bypassing the Cursed Room's door damage as well as allowing for a quick room travelling. Moreover, the skeleton is invulnerable to all damages and can be used as a cover for blocking projectiles.

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• Bad with the Bone: Tainted Forgotten uses a bone club as his main weapon, although he can only remain stationary.
• Dem Bones: Tainted Forgotten is a collapsed skeleton that cannot move on his own, although he can still swing his bone club.
• Grievous Harm with a Body: Tainted Souls' main means of attack is to throw Tainted Forgotten's skeleton at the enemies.
• Mythology Gag: Tainted Soul's hooded appearance and Tainted Forgotten's unique movement mechanic heavily resemble Edith, a cut character from the Antibirth mod.

Flies

• Big Creepy-Crawlies

Black Fly/Red Fly/Moter

• * Asteroids Monster: Moter

Boom Fly/Red Boom Fly

• Action Bomb: Black variation.

Humanoid

Gaper/Pacer/Gusher/Horfs

• Elite Mooks: Gaper have a second variety which are faster, have more health, and have no eyes.
• Eyeless Face: Gapers (See above) and Horfs
• High-Pressure Blood: Gusher
• Tears of Blood: Gapers and Horfs
• Overdrawn At the Blood Bank: Gushers, as the name implies, have a constant stream of blood flowing from their necks.

Hopper/Fire Hopper/Leaper

• Bullet Hell: See below.
• Demonic Spider: Leapers jump off the top of the screen and come down, spraying shots in 4 directions. They're also very quick. Good luck fighting a room with 3 or 4 of them!
• Elite Mooks: See above
• Infernal Retaliation: Hoppers move twice as fast, jump twice as far, and inflict more damage when they're on fire.

Maws/Mr. Maw

• Detachment Combat: Mr. Maw

Mulligan/Hive

• Body Horror
• Incurable Cough of Death
• Mook Maker: Occasionally coughs up flies and spits them at you.

Globin

• Elite Mooks: has a second variety which are faster, have more health, and (unlike Gapers) has 1 eye. As well when they are turned into a meat pile they try to run away from the player until reforming.

Knights

• Attack Its Weak Point: The front of them is solid bone or petrified flesh. The only way to actually damage it is to hit it in the back of its head, the exposed brain.
• Elite Mooks: Its second variety chases the player instead of wandering aimless. They have a crying Isaac face instead of a brain on their back.

Vis

• Body Horror
• Bloody Murder: Fires what appears to be blood in a wide beam across the room it's in.
• Elite Mooks: As of the Wrath of the Lamb DLC, Vis has a second form which shoots a beam in both directions.
• High-Pressure Blood

Baby

• Body Horror
• Elite Mooks: Has an angelic form that shoots a three spread instead of one bullet.
• Fetus Terrible
• Teleport Spam

Dople

• Elite Mooks: Instead of looking like a meat puppet. It looks like a demon that can: fly, shoot a three spread, and do more damage. Good things is that its bullets travel slower giving you time to dodge and shoot.
• Enemy Without: They mirror the player's movements, including shooting, but most rooms come with a mechanism with which to destroy them. There are also bombs, and praying that whipped shots will work.

Maggots

• Big Creepy-Crawlies

Spiders

Added with Wrath of the Lamb. A faster alternative to the flies, though they're land-bound.

• Big Creepy-Crawlies
• Demonic Spiders: Obviously YMMV, but they're far faster than the flies, and occur en masse in the Alternate levels.
• Shout-Out: One of the types of spider is a head on four legs, with a heavy-lidded eye in the center. In other words, a tektite.

Other

Clot

• Blob Monster

Clotty

• Blob Monster
• Bullet Hell: They tend to shoot haphazardly, and very often, in every direction.

Host

• Attack Its Weak Point: Only in the grey variation. To hit them you must wait for it to expose the flesh under the skull.
• The Cameo: From a multiplayer player flash game with the same name.
• No Sell: Grey Hosts are protected by their skull when they aren't firing. Trying to hit them does nothing. Trying to bomb them just annoys them. They are also immune to the Plan C pill, which can normally instantly kill all the other enemies including endgame bosses. However, they can be killed by the Chaos Card even when they are protected by their skull.

Brain and MemBrain/Mom Brain

• Asteroids Monster: MemBrain splits into two Brains when killed.

Guts

• Asteroids Monster: An example similar to Mom Brain (Mom Guts?) was added in Wrath of the Lamb.
• Body Horror

Boil

• Elite Mooks: As of Wrath of the Lamb there is a second version which shoots green bombs, much like Sloth. As well as mobile versions of each.
  • Mook Maker: There's also a version made of spider silk, which spits out spiders.

Eye

• Elite Mooks: A second version which looks like a white eyeball and nothing else. It shoots blood beams instead of electrical beams.
• Eye Scream
• Faceless Eye
• High-Pressure Blood

Leech

• Elite Mooks: A second version that has an eyeball and explodes when killed.
  • Palette Swap: There's an alternate version of that that's angelic white. Not just tinted that way, either, but a separate enemy.

The Basement/The Cellar/Burning Basement

Monstro

• Body Horror
• Degraded Boss: After the game is beaten 6 times.
• The Dev Team Thinks of Everything: One spacebar item, Monstro's Tooth, calls in the aforementioned boss to body-slam enemies. Guess which boss you can't use it against.

The Duke of Flies

• Body Horror
• Degraded Boss: After the game is beaten 6 times.
• Flunky Boss

Gemini/Steven

• Bullfight Boss: The big one can tire out after a few moments of running. If the big is killed first then the small will turn red, give chase and never tire out.
• The Cameo / Mythology Gag: Steven is from Time Fcuk.
• Dual Boss: One big version that charges the player and one small version that shoots bullets.
• Turns Red: Again, what the small one does when the big one dies.

Larry Jr.

• Asteroids Monster: Not so much as other bosses but if the middle section is killed first in a 5 body one, it will split into two more versions with just two segments.
• The Cameo / Mythology Gag: A smaller version of Larrie's Lament.
• Degraded Boss: The most common boss enemy to find in The Womb.
• King Mook: As of Wrath of the Lamb, similar enemies (Larry III?) appear.

Widow

• Flunky Boss: Not only does she spawn spiders directly, but she can also spawn Mook Maker spider silk Boils!
• King Mook: To the spiders.
• Rush Boss

Pin

• Degraded Boss: Odd variation: Pin is introduced in the new expansion as a weaker version of Scolex. Despite this, it's still a boss in its own right.
• Tactical Suicide Boss: Is not immune to it's green exploding projectiles, and due to a quirk in hit detection can actually damage itself with them when it begins to bury underground.

Baby Plum

A new boss introduced in Repentance, Baby Plum is a giant red fly with an adorable appearance, who attacks by firing arrays of bullets and propelling herself diagonally. She is originally from the Antibirth mod.

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• Bullet Hell: Her main means of attacks is to fire arrays of bullets in a set pattern.
• Last Ditch Move: If you choose to fight her and deplete her health bar, she fires a ring of projectiles when she dies.
• Sheathe Your Sword: If you spare her by not attack her for a while, she leaves the boss room while giving you the Plum Flute, an active item that allows you to summon her.

The Caves/The Catacombs/Flooded Caves

Fistula

• Asteroids Monster
• Body Horror
• Degraded Boss: Most of the time though it will already be broken down to its second stage.

Gurdy

• Body Horror
• Damage Sponge Boss
• Degraded Boss: Interestingly, the weaker version attacks very differently, charging and firing circular waves of bullets. Contrast with the other bosses made into minibosses, who are more or less identical to their original version, but weaker.
• Flunky Boss
• Stationary Boss

Peep

• Eye Scream: It detaches its eyeballs when its HP starts getting low. They block your shots and will inflict Collision Damage on you if you touch them... Oh! And they're indestructible until you kill their original owner.
• Meaningful Name: Pronounce the second p as though you were saying the letter "p".
  • There's also the fact that "peep" can mean to look at something, and he attacks you with his eyes.
• Toilet Humor: Attacks with urine.

Chub/C.H.A.D

• Bullfight Boss
• The Cameo / Mythology Gag: C.H.A.D. is a boss from Super Meat Boy.
• Degraded Boss: Another common boss enemy to find in The Depths and The Womb
• Feed It a Bomb: Has the exact same weakness as Dodongo of The Legend of Zelda fame, though he can also be beaten by regular attacks.
• Flunky Boss
• King Mook: To the maggots.

Blighted Ovum

• Back From the Dead: Gemini is now a zombie, and is accompanied by his conjoined brother's ghost.
  • The image appears to be more of a sperm and an egg.That wouldn't discredit this trope, it would just be a different set that came back, because at least the large one is undeniably dead no matter what perspective you look at it from.

The Hollow

• Back From the Dead: Larry Jr. devoid of blood.

Queen of Carrion

• Back From the Dead: A mostly-skeletal Chub.

The Husk

• Back From the Dead: The Duke of Flies' rotted corpse.
• Flunky Boss
• Rush Boss

The Depths/Necropolis/Dank Depths

Loki

• Flunky Boss
• Half the Man He Used To Be: Using the Meat Cleaver on Loki will cut him in half and turn him into Lokii.
• Tactical Suicide Boss: The boom flies it spawns will often explode on him, given how powerful you should be by the time you fight him.
• Teleport Spam

Monstro II

• Back From the Dead
• Body Horror
• Damage Sponge Boss
• Degraded Boss: In Sheol
• Flunky Boss
• High-Pressure Blood: He can fire a Brimstone beam horizontally.

Gish

• Blob Monster
• The Cameo / Mythology Gag: From a game with the same name, Gish.
• Flunky Boss
• King Mook

Mask of Infamy

• Attack Its Weak Point: The mask is invincible until you destroy it's heart. Even after that, you need to hit it from behind.
• King Mook: A beefed-up version of a standard enemy also added in Wrath of the Lamb.
• Shout-Out: Inspired by Carmillia's mask in Castlevania.

Daddy Long Legs/Triachnid

• Dummied Out: As hinted here, there was an alternate version this boss that was cut before the game was released. It wasn't removed entirely however. Due to a glitch, it originally would replace the Cathedral's True Final Boss. This was eventually corrected.
  • The Cameo / Mythology Gag: The alternate is a reference another one to another of Edmund's games. Namely, Triachnid.
  • Ascended Glitch: It is hinted that a future update will reflect this glitch somehow.
• King Mook: A giant spider, same as Widow.

Mom

Isaac's mother. In a fit rage/insanity/devoutness/whatever you think it is she attempted to take up a knife against Isaac and forced him to flee to the basement to live.

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• All There in the Manual: According to the Four Souls card game's rendition of Credit Card and Divorce Paper, her full name is Magdalene O. Moriah. Her name is also referenced in the Ascent route in Repentance, where Isaac's dad calls her "Maggy".
• Abusive Parent
• Attack of the 50 Foot Whatever: Her boss fight.
• Ax Crazy
• Big Bad
• Boss Banter: "Isaac!"
• Climax Boss: In the first playthrough.
• Death by Irony: Crushed by her own bible!
  • Gameplay and Story Integration
  • Hoist by His Own Petard
  • The Dev Team Thinks of Everything: Using the Bible instantly kills Mom. This is a reference to the epilogue at the end of the first playthrough, where she gets crushed by a falling bible.
• Disc One Final Boss: Demoted to this on your second playthrough and beyond.
• Evil Is Visceral
• Evil Laugh
• Fan Disservice: When Isaac uses the Mom's Bra item, a picture of his mother's shirtless torso flashes on the screen. A very unflattering picture of his mother's less-than-fit shirtless torso.
• Fat Bastard
• Final Boss: In your first playthrough, anyway.
• Flunky Boss
• The Fundamentalist: Influenced by the Christian broadcast that she watches, Isaac's mom has become abusive towards Isaac, first taking away all of his belongings, then attempting to murder Isaac in the name of God.
• Gonk
• Gross Up Close-Up
• Knife Nut
• Mook Maker
• Mother of a Thousand Young
• Offing the Offspring: Influenced by a voice from above, she tries to murder Isaac.
• One Bad Mother
• Say My Name: ISAAC!
• Strawman Political
• Tactical Suicide Boss: It's not actually mandatory, but making her stomp herself is possible, and deals lots of damage.
• True Final Boss: Her Heart's alternate form, It Lives, in the original version. After the Halloween Update, it becomes the Disc Three Final Boss.
• Womb Level: Defeating Mom after the first playthrough leads to the Womb and Utero, as well as Scarred Womb if it Lives has been defeated 30 times.
  • Disc One Final Dungeon
• Your Size May Vary: Just how big is she? In the cutscenes, she's a normal-sized human being, but her underwear is the right size to be worn by a child visibly smaller than her, in the boss fight her leg is the length of the screen, and then her womb is big enough to have two entire levels in it, with her heart being larger than Isaac.

Mausoleum/Gehenna

Mausoleum Mom

A new version of Mom battle introduced in Repentance, Mom at the Mausoleum has a significantly reinforced moveset, such as firing Brimstone from the eyes, repeatedly stomping Isaac 3 times before leaving a shockwave at the third stomp and such. Defeating her at the Mausoleum also unlocks a new path that can be accessed by the knife obtained by completing all two knife piece puzzles.

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Mausoleum Mom's Heart

By collecting two knife pieces from the alternate path knife puzzles and confronting Mom at the Mausoleum, Isaac can cleave open a red door at the Mausoleum Mom boss room and access Mom's Heart battle before entering the Womb. Doing so would kill off Isaac's mom before entering the Womb, leading to a new level known as the Corpse. Unlike regular Mom's Heart, it does not turn into It Lives after killing it 11 times.

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• Killed Off for Real: Defeating Mom's Heart before entering the Womb results in Isaac's mom being killed off and the subsequent level becomes the Corpse.
• Last Ditch Move: It fires a ring of projectiles as it dies.
• Womb Level: Defeating Mom's Heart at the Mausoleum leads to the Corpse, a decayed, rotting version of the Womb.

The Womb/Utero/Scarred Womb

Scolex

• Attack Its Weak Point: You can only damage it by hitting it in the very back segment.
• Fragile Speedster: It has the lowest health of any boss in the game, but it makes up for this with its speed and hard to hit weakness.

Blastocyst

• Asteroids Monster
• Blob Monster
• Degraded Boss: Very odd type. Can be found in earlier levels as a Zero Effort Boss. But later can be found in its full form.

The Bloat

• Back From the Dead: What remains of Peep's bones are broken, and his eyes swollen.
• Eye Scream
• High-Pressure Blood

Teratoma

• Asteroids Monster
• Back From the Dead: The Fistula has shrivled up and now shelters spiders.

Lokii

• Back From the Dead: Loki has been split in two, but both halves live on.
• Dual Boss
• Flunky Boss
• Half the Man He Used To Be: Lokii is the result of Loki being cut in half. Additionally, using the Meat Cleaver on Loki turns him into Lokii.
• Teleport Spam
• Visual Pun: The last two "i"s of his name have a line crossed through them on the bottom, making them resemble part of the Roman numeral II.

Mom's Heart/It Lives

• Boss Banter: Same as Mom
• Boss Rush: When it summons mooks, it also summons weaker bosses (Monstro, Larry Jr. Chub, ETC.)
• Damage Sponge Boss
• Disc Two Final Boss: Mom's Heart after the ninth playthrough
  • Disc Three Final Boss: It Lives after the Halloween update.
• The Dev Team Thinks of Everything: Using the Bible instantly kills Mom's Heart/It Lives.
• Fetus Terrible: It Lives.
• Flunky Boss: It Lives can also make Degraded Bosses.
• True Final Boss: Mom's Heart from the second through ninth playthroughs; It Lives then replaced it until the Halloween update.
• Say My Name: Same as Mom
• Word of God: It Lives is a fetus/embryo of Isaac

???/Blue Womb/Dead Womb

Hush

A variant of ???/Blue Baby that appears in the Blue Womb. According to Edumund McMillen, the lead developer of the game, Hush and the Blue Baby are one and the same, both representing Isaac's imminent death.

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• Bonus Boss: He's an optional boss which can be accessed by reaching and defeating It Lives within 30 minutes. However, it is mandatory to defeat Hush at least once in order to unlock the Void level.
• Bullet Hell: His second form primarily attacks you with arrays of bullet patterns that covers the whole stage.
• Flunky Boss: During his second form, he can summon Blue Gapers as well as flies.
• Sequential Boss: Initially, his fight is identical to ???/Blue Baby. Upon defeating Hush, he transforms into a giant head emerging from the ground and attacks you with arrays of bullet patterns as well as summoning flies and Blue Gapers.

Corpse

Mother / The Witness

• Final Boss: Of the Corpse route. Defeating Mother unlocks the Ascent route.

Sheol

Satan

• Attack of the 50 Foot Whatever: His final form
• Black Speech: During the fight with him, he sounds somewhat like this. They are actually Mom's quotes, played backwards and in a much lower tone.
• Deal with the Devil: He offers them.
• Evil Laugh
• Flunky Boss
• The Man Behind the Man: Implied
• No Sell/ Press X to Die Just try using The Bible on him.
• One-Winged Angel
• Satan
• Say My Name: Satan's battle cry when you defeat The Fallen is actually Mom calling your name, only lower pitched and in reverse.
  • Hell Is That Noise
• Sequential Boss
• Tactical Suicide Boss: Those exploding enemies he spawns don't just hurt Isaac...
• True Final Boss: One of them, as of Wrath Of The Lamb.

The Cathedral

Isaac

• Bolt of Divine Retribution: Like Conquest, can summon several pillars of light.
• Bullet Hell
• Counter Attack: In addition to the projectiles he fires periodically, he also fires at you whenever you damage him.
• Damage Sponge Boss: As of recent updates.
• Disc Four Final Boss: After being beaten while your character is holding the Polarioid, Isaac will be replaced by ??? in all subsequent runs.
• Enemy Without: Well, maybe.
• Good Counterpart: To Satan. He appears in Heaven instead of Sheol, summons angels instead of demons, and is, you know, THE PROTAGONIST.
  • May also qualify as an Evil Counterpart for the playable Isaac.
• Flunky Boss
• Holy Hand Grenade
• Messianic Archetype: Boss Isaac's One-Winged Angel
• Mirror Match
• Purposefully Overpowered: You know how almost all the items added to Wrath of the Lamb are much more powerful than the ones in the base game? There's a reason for that.
• Sequential Boss: Isaac's fight has three phases.
• True Final Boss: Alongside Satan. Until Isaac is replaced by ???
• Walking Spoiler: Given that he's the boss of the secretest (and most difficult) area of the game, yeah.

Dark Room

The Lamb

• Final Boss: Of the Dark Room level in Rebirth.

The Chest

???/Blue Baby

Posthumous version of Isaac, ??? represents the imminent death of Isaac as he suffocates in the chest.

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• Missing Secret: Previously, he would be replaced by Triachnid, due to a glitch.
• Final Boss: Of The Chest level in Rebirth.
• Sequential Boss: Similar to Isaac, ???'s fight has three phases.
• True Final Boss: Of the original game. Blue Baby replaces Isaac after Isaac is defeated when a character is holding the Polaroid. As of Rebirth, ??? is no longer the true final boss.

The Golden Gate

Mega Satan

• Final Boss: Of The Golden Gate route in Rebirth, which can be unlocked by collecting two key parts from Uriel and Gabriel by defeating them in either Angel Room or Sacrifice Room.

The Void

Delirium

The manifestation of Isaac's flashbacks before his death, Delirium takes the forms of all of the bosses that you have encountered in the playthrough and shifts its forms frequently.

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• All Your Powers Combined: It can frequently transform into any of the bosses you have encountered in the playthrough, using all of their attacks against you while firing its own array of projectiles at you.
• Bullet Hell: With its ability to transform into multiple bosses, it can quickly flood the whole room with unpredictable bullet patterns.
• Defeat Means Playable: Once you have defeated the Delirium for the first time, you can obtain the Delirious active item, which allows you to summon a friendly Delirium, who takes the form of a randomized boss enemy to assist you.
• Final Boss: Of the Void route.
• No Sell: It is immune to the Chaos Card, a consumable item which can usually instantly kill bosses or deplete a health bar for multi-phase bosses. While the Plan C pill (a pill that can instantly kill all bosses and enemies, but the user dies after 3 seconds) can instantly kill Delirium, its death animation lasts for more than 3 second and the user would likely die before Delirium's death animation ends, forfeiting the attempt. However, playing as Lazarus or owning Lazarus's Rags allows one to respawn at the same room after the pill kills the user, which makes the Plan C a viable means to instantly kill Delirium.
• True Final Boss: Of Afterbirth+. As of Repentance, Delirium is no longer the true final boss.

Home

Dogma

Voiced by: Ridiculon

The penultimate boss of Repentance and the series as a whole, Dogma is the embodiment of the Christian broadcast that corrupted Isaac's mom into a monster who tries to murder Isaac in the name of God, appearing as as a static image residing in a television screen.

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• The Corrupter: Of Isaac's mom.
• The Fundamentalist: The Dogma symbolizes a fanatical version of Christian fundamentalism, which indoctrinated Isaac's mom into becoming a fanatic who abuses and eventually trying to murder Isaac.
• Light Is Not Good: Despite its angelic appearance and holy preaching, Dogma is anything but good as it was responsible for corrupting Isaac's mom.

The Beast

The true final boss of Repentance and the series as a whole, the Beast, also referred to as the Mother of Harlots by Isaac's father at the ending narration, is a three-eyed, three-horned monstrosity residing at the Lake of Fire and is the leader of the Harbingers. It is modelled after the Beast from the Book of Revelations. It also wears the same skirt as Isaac's mom, implying that the Beast and Isaac's mom are one and the same.

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• Boss Rush: At the beginning of the fight, the Beast sends the Ultra versions of the Four Horsemen to confront you. You have to defeat all four of them first before you can fight against the Beast itself.
• True Final Boss: Of Repentance and the series as a whole. Defeating the Beast unlocks the true ending.

The Seven Deadly Sins

Envy/Super Envy

• Asteroids Monster

Gluttony/Super Gluttony

• High-Pressure Blood
• King Mook: He's basically a Vis with a head.

Greed/Super Greed

• Chest Monster
• Flunky Boss
• Mook Promotion: Given that he is the same size as all the other Greed mooks and item holders, Greed as a mini-boss could be this.
  • King Mook: Super Greed, however, is bigger and can spawn more Greed heads.
• The Scrappy: Given how he can replace shops and secret rooms, can knock out your money when he hits you, and can be fought multiple times in one run, players usually don't enjoy finding him.
• Shop Keeper: When he isn't hostile.

Ultra Greed

A hulking, gigantic variant of Greed that appears at the end of the Greed Mode. He has a vastly different moveset compared to the default Greed.

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• Abnormal Ammo: He throws coins as his ammunitions, bombs and monster summoning trinkets.
• Final Boss: Of the Greed Mode.
• Flunky Boss: He can summon Greed Gapers by throwing Key Coins, which opens the gates around the boss room and sends hordes of Greed Gapers into the room.
• King Mook: Of both Greed and Super Greed.
• Lightning Bruiser: Despite his huge size, Ultra Greed is surprisingly agile as he moves by spinning and dancing around the field.

Lust/Super Lust

• Bullfight Boss

Sloth/Super Sloth

• Palette Swap: Of the Globin. See below.
• Stealth Pun: Unlike the other sins, Sloth is a Palette Swap of an existing enemy. Sloth has a lazy character design.

Wrath/Super Wrath

• Cartoon Bomb
• Expy: Of Bomberman.

Harbingers

• Horsemen of the Apocalypse

Famine

• Degraded Boss: In later stages.

Pestilence

• Degraded Boss: In later stages.

War

• Bullfight Boss: After losing his horse.
• Degraded Boss: In later stages.

Death

• Degraded Boss: In later stages.
• Shout-Out: One of his attacks is very similar to one that a certain other Death you may know of uses.
• Sinister Scythe

Headless Horseman

• Degraded Boss: In later stages. Usually found as two or three copies of its head in the same room.
• Dual Boss: The boss is split into: his head, that charges and shoots small bullets, and his body, which shoots large bombs and leaves trails of blood.
• Headless Horseman: Well yeah.

Conquest

• Bolt of Divine Retribution: One of only two bosses in the game to summon beams of light from on high.
• Doppelganger Attack
• Blindfold Of Power
• Holy Hand Grenade

Other

The Fallen

• Asteroids Monster: After about 75% of his health his gone he splits into two versions of himself.
• Bullfight Boss: Does this when he isn't shooting. After his charging sequence he'll shoot blood in every direction.
• Degraded Boss: In later stages.
• The Dragon: To Satan
• High-Pressure Blood

Krampus

• Bad Santa: Drops a Lump of Coal.
• Chest Monster: Randomly appears in Devil Rooms.
• High-Pressure Blood
• The Krampus
• Palette Swap: Of The Fallen.

The Wretched

• Degraded Boss: Currently the only way he appears. He himself is a Degraded Boss of Gurdy.
• Dummied Out / Missing Secret: Clearly intended to be a boss; however he never appears as one.

The Narrator / Isaac's Dad

The narrator of the story, as well as the announcer of pill effects and tarot card effects. He's also Isaac's father, who encourages Isaac to use his imagination to create an adventure.

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• The Gambling Addict: Implied to be one of the two reasons that causes him to steal Isaac's mom's money and leave his family, along with his wife's fanaticism. There are glimpses of his obsession with money, such as Bumbo's love for coin, the Dad's Lost Coin item, slot machines and gamblers at the arcade room and and the prevalence of Greed's presence.
• Good Parent: In stark contrast to his wife, he deeply cares about his son's wellbeing. He also encourages his son to unleash his creativity and build a world, as seen in the final ending The Legend of Bum-bo. He also encourages Isaac to give a happy ending to the story in the final ending of Repentance.
• Narrator All Along: As revealed in the prequel game The Legend of Bum-bo as well as the Ascent route and true ending of Repentance, the narrator turns out to be Isaac's father.
• Screw This, I'm Outta Here: He's fed up with his wife's religious fanaticism and decides to break up with his wife. As he leaves the family, he apologizes to Isaac, which reveals that he's the narrator of the story.