Since the medium of comics arguably originated in the USA, it should come as no surprise that a whole lot of comics are American. Also included here are Canadian comics, as they are for the most part pretty similar to their southern counterparts due to the large amount of intermingling between the two cultures, businesses and talents, and often see distribution in both regions regardless of origin.
- Antarctic Press
- Archaia Entertainment
- Archie Comics
- Avatar Press
- Bongo Comics
- Boom Studios
- Chaos! Comics
- Charlton Comics
- Cinebook
- Cross Gen
- Dark Horse Comics
- DC Comics
- DC Comics Series
- All Star DC Comics
- Tangent Comics
- Vertigo Comics
- Wildstorm
- Milestone Comics (associated publisher. Milestone retains the copyrights while DC owns the trademarks)
- Dell Comics
- Dynamite Comics
- EC Comics
- Eclipse Comics
- Fawcett Comics
- Games Workshop
- Grayhaven Comics
- Harvey Comics
- Heroic Publishing
- Icon Comics
- Image
- Man of Action Studios
- Marvel Comics
- Mystic Studios Productions
- Rip Off Press
- Strawberry Comics
- Tokyo Pop
- Valiant Comics
Misc US/Canadian comic book companies and comics:
Aardvark-Vanaheim[]
Abrams ComicArts[]
ACC Studios[]
Ait / Planet Lar[]
- Demo
- The Couriers
Antarctic Press[]
Arcana Studio[]
Archaia[]
Aspen MLT[]
Black Bull[]
Broadsword Comics[]
- Tarot: Witch of the Black Rose
- School Bites (Now a webcomic)
Broadway Books[]
Caliber[]
Comico[]
Comics Interview[]
Continuity Comics[]
Department Of the Army[]
Devil's Due[]
Disney[]
- Abadazad
- Donald Duck
- Dragonlords
- Jellaby
- The Legend of the Chaos God
- The Life and Times of Scrooge McDuck
- The Incredibles
- Wizards of Mickey
Dork Storm Press[]
Dragon[]
Eros Comix[]
Event Comics[]
Evil Twin Comics[]
Fantagraphics[]
- Bitchy Bitch
- Bitchy Butch
- Black Hole
- Castle Waiting
- Eightball
- Frank
- Love and Rockets
- Peculia
- Small Favors
First Comics[]
First Second[]
Fishwrap[]
Hannagram[]
Harper Perennial[]
Harper Teen[]
IDW[]
- Fallen Angel
- G.I. Joe
- Kill Shakespeare
- The Life and Times of Savior 28
- Life Sucks
- Locke and Key
- Love and Capes
- The Maze Agency
- Teenage Mutant Ninja Turtles (IDW)
- Transformers Generation 1
- Wynonna Earp
Innovation[]
Kenzer[]
King Features[]
LEGO[]
Mariner Books[]
Minx[]
Mirage Publishing[]
- Gizmo
- Teenage Mutant Ninja Turtles (Original Continuity)
National Hockey League[]
NEC[]
Nedor Comics[]
Nuage Editions[]
Octopus[]
Oni Press[]
- The Adventures of Barry Ween
- Blue Monday
- Courtney Crumrin and the Night Things
- The Good Neighbors
- Jingle Belle
- Local
- Lost At Sea
- Polly and The Pirates
- Queen and Country
- Scott Pilgrim
- Scooter Girl
- Stumptown
- The View Askewniverse
- Wet Moon
- Whiteout
Pantheon Books[]
Paws[]
Platinum Studios[]
Radical Comics[]
Red 5[]
Roaring Book Press[]
Sega[]
Scholastic[]
Shanda Fantasy Arts[]
Simon & Schuster[]
Slave Labor Graphics[]
- Dead Eyes Open
- Fun With Milk and Cheese
- Hsu and Chan
- I Feel Sick
- Johnny the Homicidal Maniac
- Lenore the Cute Little Dead Girl
- Nightmares and Fairy Tales
- Pepper Penwell and The Land Creature of Monster Lake
- Rex Libris
- Serenity Rose
- Shadoweyes
- Squee
- Widgey Q Butterfluff
Studio Foglio[]
Tekno Comix[]
Top Shelf[]
Topps[]
Tower Comics[]
Tundra Comics[]
UDON[]
United Feature Syndicate[]
Villard[]
Viper Comics[]
Zenescope[]
Independently published[]
- Action Girl
- American Mcgees Grimm
- American Splendor (though later picked up by Dark Horse and then DC Vertigo)
- Body Bags
- Bone
- Bookhunter
- Cavewoman
- Cherry Comics
- Chick Tracts
- Circles
- City of Dreams
- A Distant Soil
- The Desert Peach
- Double Happiness
- Dracula vs. King Arthur
- Echo
- Electric Girl
- Elf Quest
- Finder
- Fritz the Cat
- Funnyman
- Garfield Minus Garfield
- Gear (originally published independently, reprinted later by Image Comics)
- Katman
- Lady Death (technically, multiple publishers, including at least two defunct ones)
- Let's Kill All the Belgians: A Child's Guide to Genocide
- Life Sucks
- Limekiller At Large
- Meanwhile
- Mr. A
- The Pertwillaby Papers
- PS238
- Rapunzels Revenge
- Reid Fleming Worlds Toughest Milkman
- The Rocketeer (changed publishers every few issues, passing through Pacific, Eclipse, Comico, and Dark Horse before ending up with IDW)
- Sonic the Hedgehog 1991
- Strangers in Paradise
- The Stuff of Legend
- Tanpopo
- Tank Vixens
- Therefore Repent!
- Thieves and Kings
- Too Much Coffee Man
- Transformers Generation One Dreamwave
- Transformers Timelines
- Treasure Chest
- True Story Swear to God
- Twisted Toyfare Theater
- Underburbs
- The Unfunnies
- Vögelein
- Warrior