Mass Effect 2 has a slight case of this in Joker. Shepard dies at the start of the game specifically because Joker refused to leave the Normandy when it was going down in flames. Shepard was forced to pull off a Heroic Sacrifice for him. Despite this, Joker is still a popular character, but it did earn him some haters.
Shepard wasn't under any obligation to save Joker, so it's really his/her own fault being too sentimental about his/her crew.
S/he got better...
When you become captain of a ship, you take responsibility for her as well as anyone onboard. It's a long-time naval tradition, and it likely persisted in the Space Navy. What kind of a captain abandons a crewmember? Besides, Shepard probably thought Joker couldn't make it on his own due to his disability. And Joker's a friend. Throw in the fact that Joker kept the badly-damaged Normandy flying for long enough for the rest of the surviving crew to abandon ship, and you realise that Shepard gave his/her life to save the guy that saved everyone else.
The Ace Attorney games have one (although it's more attributed to the series being a Long Runner more than anything): Tsukasa Oyashiki/Katherine Hall is indirectly responsible for the DL-6 incident, thanks to inadvertently hiding the IS-7 victim's body. This was due to the fact that she was trying to prevent the destruction of some ice statues made by the victim, and didn't even know the killer hid the body there. Because of that, she's responsible for the forgery of evidence and Manfred von Karma's black spot on his perfect record.
And to really make things worse, the DL-6 Incident lead to the Feys losing their reputation, causing Morgan's husband to leave her and Dahlia to grow up to become a serial killer. Poor Tsukasa/Katherine's got a lot of blood on her hands.
Jake Marshall can be considered one for Case 1-5. He approaches Bruce Goodman, asking him to re-open SL-9, but Goodman refuses. Marshall then steals Goodman's ID to retrieve the evidence himself, prompting Goodman to have to enter the evidence room with Police Chief Damon Gant in order to complete the transferal. Not realizing he was with Neil Marshall's true killer, Goodman changes his mind and suggests reopening the case, and is killed on the spot before being transported to the underground parking lot. Marshall thus, either by stealing Goodman's ID or planting a seed of doubt in Goodman, indirectly caused Goodman's death.
Final Fantasy X: So Yuna and her friends have uncovered the truth about Maester Seymour, and are getting ready to send his ass to the Farplane, when Trommel intervenes and interrupts the ritual. It Gets Worse when, Trommel, after being confronted with Seymour's wrongdoing destroys the sphere of Seymour's father warning about his son's Start of Darkness, with the excuse that "the Guado deal with Guado affairs." Needless to say, with this action, Yuna and company are forced into hostile terms with not just the Guado, but the entirety of Spira as well, and the unsent Seymour goes on to attack the party several times, proving to be a deadly recurring villain. The decision does later cause trouble for the Guado when Seymour nearly wipes out the Ronso, leading to the near retaliatory genocide of the Guado in the sequel.
In the "Invasion of the Firelands" quest chain in World of Warcraft, the players can become one in a rare instance in which they cause disaster without being an Unwitting Pawn. Shortly before the attack on the Firelands is about to begin, Hamuul asks the player to investigate a Druid of the Flame nearby. The Druid of the Flame, Leyara, attacks the player and Hamuul, badly burning Hamuul and preventing the protectors of Hyjal from going on the offensive until the player gets enough Marks of the World Tree to unlock the next phase of daily quests.
Ryousuke Katayama of Corpse Party is a weird example, in that it's not exactly his fault. In Tenjin Elementary School, he loses his leg in a trap and bleeds to death. His friend Ohkawa, however, insists that he's still alive and needs to get to a hospital. In an attempt to "help" him realize the truth, Kizami pushes his body down the stairs. This works about as well as you'd expect. Ohkawa calls Kizami a murderer, which causes Kizami to have an "epiphany": It doesn't matter whether it's the school that kills you or him. Ultimately, Kizami punches out Touko's front tooth, kills Ohkawa, Fukuroi, and Mitsuki, stabs his childhood friend Kurosaki and kicks him into a pit, then brutally murders him when he finds out he survived, and tries to kill a girl he'd been trying to help find her brother before finally being killed by the zombie guy that's been running around.
During Hanako's route in the Visual NovelKatawa ShoujoMisha decides to teasingly question her and Hisao about their realtionship as a result of this queston Hisao is forced into a situation where he forced to tell Hanako about the suprise birthday party that he and Lily were planning for her. This just happens to cause Hanako to have a panic attack. To be fair, she truly didn't know that birthdays are a Trigger for Hanako and not only she's horrified when she breaks down, but apologizes as soon as she can and means it with all of her heart.
In BastionThe Manipulative Bastard who seduced and betrayed Zia indirectly caused The Calamity by driving Zia's father into sabotaging it and getting the Mancers panicked enough to set it off.
Two very active "active parts" in this horror tale are Kinzo Ushiromiya and his daughter-in-law Natsuhi. The first raped his illegitimate daughter Beatrice Ushiromiya, who he kept locked away from the world, and had a child with her. Then, the second was "given" the infant to raise since she and her husband couldn't have a kid of their own, but she saw it as an insult to her worth as a woman, and at some point she snapped and pushed a servant that was taking care of the poor baby off a cliff. The servant died, and while the kid survived they suffered severe injuries and especially to their sexual organs, and from then on was raised as a servant - and became Sayo Yasuda aka Shannon aka Beatrice.
Rudolf and Kyrie Ushiromiya could be said to have kept the whole "horror tale" going, too. Because had they not married too soon for Battler's taste, he wouldn't have broken off with his paternal family... and therefore he would've been there for the aforementioned Sayo/Yasu and found a way to help them deal with their terrible life, which would've probably kept them from snapping and going the Kill 'Em All way...
A good part of Rosa and Maria's HORRIBLE issues can be traced to Maria's birth father abandoning Rosa when she was still pregnant, under the promise of finding a job that would get them out of the gigantic debt they were in due to a co-loan they signed. The trauma coming from this and Rosa's own past where she was intensely bullied by her own family, plus the stress of being a single mother in a country that heavily discriminates unwed moms, led Rosa to crack and become a gigantic Troubled Abuser towards Maria.
In Tekken 7, the late Kazumi Mishima is revealed to have been one. First: the Devil Gene comes from her. Second: under the orders of her people, Kazumi directly tried to kill Heihachi despite her love for him, and ended up dead for it. Third: when Heihachi killed her in self-defense, near all his remaining goodness (which was already dwindling) was gone, and soon everything in the story started going to shit. As seen in the Story Mode, she's very unhappy about her part on all of this.
